Surette FA, Guthmiller JJ, Li L, Sturtz AJ, Vijay R, Pope RL, McClellan BL, Pack AD, Zander RA, Shao P, Lan LY, Fernandez-Ruiz D, Heath WR, Wilson PC, Butler NS. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathog. 2021 Feb 2;17(2):e1009288. doi: 10.1371/journal.ppat.1009288

Jensen IJ, McGonagill PW, Butler NS, Harty JT, Griffith TS, Badovinac VP. NK Cell-Derived IL-10 Supports Host Survival during Sepsis. Journal of Immunology. 2021 Jan 29:ji2001131. doi: 10.4049/jimmunol.2001131

Vijay, R., Guthmiller, J.J., Sturtz, A.J. et al. Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nature Immunology (2020). https://doi.org/10.1038/s41590-020-0678-5

Rogers KJ, Shtanko O, Vijay R, Mallinger LN, Joyner CJ, Galinski MR, Butler NS, Maury W. Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection. Cell Reports. 2020 Mar 24;30(12):4041-4051.e4. doi: 10.1016/j.celrep.2020.02.104. PMID: 32209467

Brunton B, Rogers K, Phillips EK, Brouillette RB, Bouls R, Butler NS, Maury W. TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis. PLoS Neglected Tropical Diseases. 2019 Jun 26;13(6):e0006983. doi: 10.1371/journal.pntd.0006983. eCollection 2019 Jun. PMID: 31242184

Kurup SP, Butler NS, Harty JT. T cell-mediated immunity to malaria. Nature Reviews Immunology. 2019 Jul;19(7):457-471. doi: 10.1038/s41577-019-0158-z. Review. PMID: 30940932

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M. cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. eCollection 2018 Jan 25. PMID: 29367469

Smith, L. K., Boukhaled, G. M., Condotta, S. A., Mazouz, S., Guthmiller, J. C., Vijay, R., Butler, N. S., Bruneau, J., Shoukry, N. H., Krawczyk, C. M. & Richer, M. J. (2018). Interleukin-10 Directly Inhibits CD8+T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity. (Vols. 48). pp. 1-14. ImmunityDOI: doi.org/10.1016/j.immuni.2018.01.006.

Huggins, M. A., Johnson, H. L., Jin, F., N'Songo, A., Hanson, L. M., LaFrance, S. J., Butler, N. S., Harty, J. T. & Johnson, A. J. (2017). Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infection & Immunity, 85(5), e00985-16. PMID: 28264905.

Niu, G., Franca, C., Roobsoong, W., Nguitragool, W., Wang, X., Prachumsri, J., Butler, N. S. & Li, J. (2017). Fibrinogen domain of FREP1 is a broad spectrum malaria transmission-blocking vaccine antigen. Journal of Biological Chemistry, 292(28), 11960-11969. PMID: 28533429.

Guthmiller, J. J., Graham, A. C., Zander, R. A., Pope, R. L. & Butler, N. S. (2017). Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. J Immunol, 198(2), 617-22. PMID: 27940658.

Kurup, S. A., Obeng-Adjei, N., Anthony, S. M., Traore, B., Doumbo, O. K., Butler, N. S., Crompton, P. D. & Harty, J. T. (2017). Regulatory T cells impede acute and long-term immunity to blood stage malaria through CTLA-4. Nature Medicine. PMID: 28892065.

Zander, R. A., Vijay, R., Pack, A. D., Guthmiller, J. J., Graham, A. C., Lindner, S. E., Vaughan, A. M., Kappe, S. H. & Butler, N. S. (2017). Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity. Cell ReportsPMID: 29141217.

Rivera-Correa, J., Guthmiller, J. J., Vijay, R., Fernandez-Arias, C., Pardo-Ruge, M. A., Butler, N. S., Gonzalez, S. & Rodriguez, A. (2017). Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria. (Vols. 1). (8), pp. 1282. Nature CommunicationsPMID: 29101363.

Richer, M. J., Lang, M. L. & Butler, N. S. (2016). T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. J Immunol, 197(4), 1009-15. PMID: 27496973.

Zander, R. A., Guthmiller, J. J., Graham, A. C., Pope, R. L., Burke, B. E., Carr, D. J. & Butler, N. S. (2016). Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathogens, 12(10), e1005945. PMID: 27732671.

Butler, N. S., Schmidt, N. W. (2015). Erythropoietin-producing hepatocellular receptor B2 receptor tyrosine kinase: A novel regulator of infection- and inflammation-induced liver fibrosis. (Vols. 62). (3), pp. 680-3. HepatologyPMID: 25914283.

Guthmiller, J. J., Zander, R. A. & Butler, N. S. (2015). Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice. In  Methods Mol Biol. pp. 19-37.  PMID: 26450376.

Butler, N. S., Kulu, D. I. (2015). The regulation of T follicular helper responses during infection. Curr Opin Immunol, 34, 68-74. PMID: 25726751.

Zhang, G., Niu, G., Franca, C. M., Dong, Y., Wang, X., Butler, N. S., Dimopoulos, G. & Li, J. (2015). Anopheles Midgut FREP1 Mediates Plasmodium Invasion. J Biol Chem, 290(27), 16490-501. PMID: 25991725.

Zander, R. A., Obeng-Adjei, N., Guthmiller, J. J., Kulu, D. I., Li, J., Ongoiba, A., Traore, B., Crompton, P. D. & Butler, N. S. (2015). PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host & Microbe, 17(5), 628-41.PMID: 25891357.

Doll, K. L., Butler, N. S. & Harty, J. T. (2014). CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii. Vaccine, 32(4), 483-91. PMID: 24321740.

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. T., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W. (2014). The cellular redox environment alters antigen presentation. J Biol Chem, 289(40), 27979-91. PMID: 25135637.

Doll, K. L., Butler, N. S. & Harty, J. T. (2013). Tracking the total CD8 T cell response following whole Plasmodium vaccination. Methods Mol Biol, 923, 493-504. PMID: 22990800.

Zander, R. A., Butler, N. S. (2013). Dysfunctional adaptive immunity during parasitic infections. Curr Immunol Rev, 9(3), 179-89. PMID: 24839433.

Butler, N. S. (2013). Vaccination Against Malaria Parasites: Paradigms, Perils and Progress. In M. Geist (Eds.) Molecular Vaccines-From Prophylaxis to Therapy. Vienna: Springer Press.

Illingworth, J., Butler, N. S., Roetynck, S., Mwacharo, J., Pierce, S. K., Bejon, P., Crompton, P. D., Marsh, K. & Ndungu, F. M. (2013). Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol, 190(3), 1038-47. PMID: 23264654.

Butler, N. S., Harris, T. H. & Blader, I. J. (2013). Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?. Trends Parasitol, 29(12), 593-602. PMID: 24184186.

Butler, N. S., Vaughan, A. M., Harty, J. T. & Kappe, S. H. (2012). Whole parasite vaccination approaches for prevention of malaria infection. Trends Immunol, 33(5), 247-54. PMID: 22405559.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2011). Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol, 186(10), 5873-84. PMID: 21460205.

Butler, N. S., Nolz, J. C. & Harty, J. T. (2011). Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol, 13(7), 925-33. PMID: 21501363.

Butler, N. S., Schmidt, N. W., Vaughan, A. M., Aly, A. S., Kappe, S. H. & Harty, J. T. (2011). Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host & Microbe, 9(6), 451-62. PMID: 21669394.

Butler, N. S., Moebius, J., Pewe, L. L., Traore, B., Doumbo, O. K., Tygrett, L. T., Waldschmidt, T. J., Crompton, P. D. & Harty, J. T. (2011). Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nature Immunology, 13(2), 188-95. PMID: 22157630.

Schmidt, N. W., Butler, N. S., Badovinac, V. P. & Harty, J. T. (2010). Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathogens, 6(7), e1000998. PMID: 20657824.

Butler, N. S., Schmidt, N. W. & Harty, J. T. (2010). Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J Immunol, 184(5), 2528-38. PMID: 20097864.

Butler, N. S., Harty, J. T. (2010). The role of inflammation in the generation and maintenance of memory T cells. In  Adv Exp Med Biol. pp. 42-56.  PMID: 20795539.

Butler, N. S., Harty, J. T. (2009). A "memorable" NK cell discovery. (Vols. 19). (3), pp. 277-8. Cell ResearchPMID: 19252510.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2009). CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge. Vaccine, 27(44), 6103-6. PMID: 19712771.

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol, 180(6), 3926-37. PMID: 18322201.

Schmidt, N. W., Podyminogin, R. L., Butler, N. S., Badovinac, V. P., Tucker, B. J., Bahjat, K. S., Lauer, P., Reyes-Sandoval, A., Hutchings, C. L., Moore, A. C., Gilbert, S. C., Hill, A. V., Bartholomay, L. C. & Harty, J. T. (2008). Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A, 105(37), 14017-22. PMID: 18780790.

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. PLoS Pathog, 4(10), e1000186. PMID: 18949029.

Butler, N. S., Dandekar, A. A. & Perlman, S. (2007). Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus. J Virol, 81(24), 13291-8. PMID: 17913802.

Perlman, S., Butler, N. (2006). Neurotropic coronavirus infections. In C. S. Reiss (Eds.) Neurotropic Viral Infections. New York: Cambridge University Press.

Yarovinsky, T. O., Butler, N. S., Monick, M. M. & Hunninghake, G. W. (2006). Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. J Immunol, 177(7), 4426-35. PMID: 16982877.

Butler, N., Pewe, L., Trandem, K. & Perlman, S. (2006). Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology, 347(2), 410-21. PMID: 16413043.

Ashare, A., Powers, L. S., Butler, N. S., Doerschug, K. C., Monick, M. M. & Hunninghake, G. W. (2005). Anti-inflammatory response is associated with mortality and severity of infection in sepsis. Am J Physiol Lung Cell Mol Physiol, 288(4), L633-40. PMID: 15579629.

Monick, M. M., Cameron, K., Powers, L. S., Butler, N. S., McCoy, D., Mallampalli, R. K. & Hunninghake, G. W. (2004). Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol, 30(6), 844-52. PMID: 14742298.

Chung, M. P., Monick, M. M., Hamzeh, N. Y., Butler, N. S., Powers, L. S. & Hunninghake, G. W. (2003). Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol, 29(3 Pt 1), 375-80. PMID: 12676806.

Monick, M. M., Powers, L. S., Butler, N. S. & Hunninghake, G. W. (2003). Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. J Immunol, 171(5), 2625-30. PMID: 12928415.

Monick, M. M., Samavati, L., Butler, N. S., Mohning, M., Powers, L. S., Yarovinski, T., Spitz, D. R. & Hunninghake, G. W. (2003). Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol, 171(10), 5107-15. PMID: 14607909.

Yarovinsky, T. O., Powers, L. S., Butler, N. S., Bradford, M. A., Monick, M. M. & Hunninghake, G. W. (2003). Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance. J Immunol, 171(5), 2453-60. PMID: 12928393.

Monick, M. M., Yarovinsky, T. O., Powers, L. S., Butler, N. S., Carter, A. B., Gudmundsson, G. & Hunninghake, G. W. (2003). Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem, 278(52), 53035-44. PMID: 14565959.

Nyunoya, T., Powers, L. S., Yarovinsky, T. O., Butler, N. S., Monick, M. M. & Hunninghake, G. W. (2003). Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein. J Biol Chem, 278(38), 36099-106. PMID: 12847100.

Monick, M. M., Powers, L., Butler, N., Yarovinsky, T. & Hunninghake, G. W. (2002). Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol, 283(2), L390-402. PMID: 12114201.

Monick, M. M., Robeff, P. K., Butler, N. S., Flaherty, D. M., Carter, A. B., Peterson, M. W. & Hunninghake, G. W. (2002). Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem, 277(36), 32992-3000. PMID: 12072439.

Butler, N. S., Monick, M. M., Yarovinsky, T. O., Powers, L. S. & Hunninghake, G. W. (2002). Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol, 169(7), 3700-9. PMID: 12244163.