Inoue T, Shinnakasu R, Kawai C, Yamamoto H, Sakakibara S, Ono C, Itoh Y, Terooatea T, Yamashita K, Okamoto T, Hashii N, Ishii-Watabe A, Butler NS, Matsuura Y, Matsumoto H, Otsuka S, Hiraoka K, Teshima T, Murakami M, Kurosaki T. Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees. Journal of Experimental Medicine. 2023 Feb 6;220(2):e20221786. doi: 10.1084/jem.20221786. Epub 2022 Dec 13. PMID: 36512034; PMCID: PMC9750191.

Koike T, Fujii K, Kometani K, Butler NS, Funakoshi K, Yari S, Kikuta J, Ishii M, Kurosaki T, Ise W. Progressive differentiation toward the long-lived plasma cell compartment in the bone marrow. Journal of Experimental Medicine. 2023 Feb 6;220(2):e20221717. doi: 10.1084/jem.20221717. Epub 2022 Dec 14. PMID: 36515679; PMCID: PMC9754767.

Surette FA, Butler NS. Temporally Evolving and Context-Dependent Functions of Cytokines That Regulate Murine Anti-Plasmodium Humoral Immunity. Pathogens. 2022 Apr 29;11(5):523. doi: 10.3390/pathogens11050523. PMID: 35631044 

Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Reports. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956.PMID: 34731605

Pack AD, Schwartzhoff PV, Zacharias ZR, Fernandez-Ruiz D, Heath WR, Gurung P, Kevin, Legge KL, Janse CJ and Butler NS. Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity. Cell Reports. 2021 Aug 24;36(8):109586. doi: 10.1016/j.celrep.2021.109586. PMID: 34433049

Anthony SM, Van Braeckel-Budimir N, Moioffer SJ, van de Wall S, Shan Q, Vijay R, Sompallae R, Hartwig SM, Jensen IJ, Varga SM, Butler NS, Xue HH, Badovinac VP, Harty JT. Protective function and durability of mouse lymph node-resident memory CD8+T cells. eLife. 2021 Jun 18;10:e68662. doi: 10.7554/eLife.68662.

Vijay R, Guthmiller JJ, Sturtz AJ, Crooks S, Johnson JT, Li L, Lan LY, Pope RL, Chen Y, Rogers KJ, Dutta N, Toombs JE, Wilson ME, Wilson PC, Maury W, Brekken RA, Butler NS. Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation. Journal of Experimental Medicine. 2021 Jun 7;218(6):e20202359. doi: 10.1084/jem.20202359.

Rogers KJ, Vijay R, Butler NS. Anti-malarial humoral immunity: the long and short of it. Microbes and Infection. 2021 Mar 5:104807. doi: 10.1016/j.micinf.2021.104807. Online ahead of print.PMID: 33684519

Surette FA, Guthmiller JJ, Li L, Sturtz AJ, Vijay R, Pope RL, McClellan BL, Pack AD, Zander RA, Shao P, Lan LY, Fernandez-Ruiz D, Heath WR, Wilson PC, Butler NS. Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity. PLoS Pathogens. 2021 Feb 2;17(2):e1009288. doi: 10.1371/journal.ppat.1009288

Jensen IJ, McGonagill PW, Butler NS, Harty JT, Griffith TS, Badovinac VP. NK Cell-Derived IL-10 Supports Host Survival during Sepsis. Journal of Immunology. 2021 Jan 29:ji2001131. doi: 10.4049/jimmunol.2001131

Vijay, R., Guthmiller, J.J., Sturtz, A.J. Surette FA, Rogers KJ, Sompallae RR, Li F, Pope RL, Chan JA, de Labastida Rivera F, Andrew D, Webb L, Maury WJ, Xue HH, Engwerda CR, McCarthy JS, Boyle MJ, Butler NS. Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nature Immunology (2020).

Rogers KJ, Shtanko O, Vijay R, Mallinger LN, Joyner CJ, Galinski MR, Butler NS, Maury W. Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection. Cell Reports. 2020 Mar 24;30(12):4041-4051.e4. doi: 10.1016/j.celrep.2020.02.104. PMID: 32209467

Brunton B, Rogers K, Phillips EK, Brouillette RB, Bouls R, Butler NS, Maury W. TIM-1 serves as a receptor for Ebola virus in vivo, enhancing viremia and pathogenesis. PLoS Neglected Tropical Diseases. 2019 Jun 26;13(6):e0006983. doi: 10.1371/journal.pntd.0006983. eCollection 2019 Jun. PMID: 31242184

Kurup SP, Butler NS, Harty JT. T cell-mediated immunity to malaria. Nature Reviews Immunology. 2019 Jul;19(7):457-471. doi: 10.1038/s41577-019-0158-z. Review. PMID: 30940932

Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr, Liles WC, Pepper M. cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. eCollection 2018 Jan 25. PMID: 29367469

Smith, L. K., Boukhaled, G. M., Condotta, S. A., Mazouz, S., Guthmiller, J. C., Vijay, R., Butler, N. S., Bruneau, J., Shoukry, N. H., Krawczyk, C. M. & Richer, M. J. (2018). Interleukin-10 Directly Inhibits CD8+T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity. (Vols. 48). pp. 1-14. ImmunityDOI:

Huggins, M. A., Johnson, H. L., Jin, F., N'Songo, A., Hanson, L. M., LaFrance, S. J., Butler, N. S., Harty, J. T. & Johnson, A. J. (2017). Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infection & Immunity, 85(5), e00985-16. PMID: 28264905.

Niu, G., Franca, C., Roobsoong, W., Nguitragool, W., Wang, X., Prachumsri, J., Butler, N. S. & Li, J. (2017). Fibrinogen domain of FREP1 is a broad spectrum malaria transmission-blocking vaccine antigen. Journal of Biological Chemistry, 292(28), 11960-11969. PMID: 28533429.

Guthmiller, J. J., Graham, A. C., Zander, R. A., Pope, R. L. & Butler, N. S. (2017). Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. The Journal of Immunology. 198(2), 617-22. PMID: 27940658.

Kurup, S. A., Obeng-Adjei, N., Anthony, S. M., Traore, B., Doumbo, O. K., Butler, N. S., Crompton, P. D. & Harty, J. T. (2017). Regulatory T cells impede acute and long-term immunity to blood stage malaria through CTLA-4. Nature Medicine. PMID: 28892065.

Zander, R. A., Vijay, R., Pack, A. D., Guthmiller, J. J., Graham, A. C., Lindner, S. E., Vaughan, A. M., Kappe, S. H. & Butler, N. S. (2017). Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity. Cell ReportsPMID: 29141217.

Rivera-Correa, J., Guthmiller, J. J., Vijay, R., Fernandez-Arias, C., Pardo-Ruge, M. A., Butler, N. S., Gonzalez, S. & Rodriguez, A. (2017). Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria. (Vols. 1). (8), pp. 1282. Nature CommunicationsPMID: 29101363.

Richer, M. J., Lang, M. L. & Butler, N. S. (2016). T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. The Journal of Immunology, 197(4), 1009-15. PMID: 27496973.

Zander, R. A., Guthmiller, J. J., Graham, A. C., Pope, R. L., Burke, B. E., Carr, D. J. & Butler, N. S. (2016). Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathogens, 12(10), e1005945. PMID: 27732671.

Butler, N. S., Schmidt, N. W. (2015). Erythropoietin-producing hepatocellular receptor B2 receptor tyrosine kinase: A novel regulator of infection- and inflammation-induced liver fibrosis. (Vols. 62). (3), pp. 680-3. HepatologyPMID: 25914283.

Guthmiller, J. J., Zander, R. A. & Butler, N. S. (2015). Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice. In  Methods Mol Biol. pp. 19-37.  PMID: 26450376.

Butler, N. S., Kulu, D. I. (2015). The regulation of T follicular helper responses during infection. Current Opinion in Immunology, 34, 68-74. PMID: 25726751.

Zhang, G., Niu, G., Franca, C. M., Dong, Y., Wang, X., Butler, N. S., Dimopoulos, G. & Li, J. (2015). Anopheles Midgut FREP1 Mediates Plasmodium Invasion. Journal of Biological Chemistry, 290(27), 16490-501. PMID: 25991725.

Zander, R. A., Obeng-Adjei, N., Guthmiller, J. J., Kulu, D. I., Li, J., Ongoiba, A., Traore, B., Crompton, P. D. & Butler, N. S. (2015). PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host & Microbe, 17(5), 628-41.PMID: 25891357.

Doll, K. L., Butler, N. S. & Harty, J. T. (2014). CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii. Vaccine, 32(4), 483-91. PMID: 24321740.

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. T., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W. (2014). The cellular redox environment alters antigen presentation. Journal of Biological Chemistry, 289(40), 27979-91. PMID: 25135637.

Doll, K. L., Butler, N. S. & Harty, J. T. (2013). Tracking the total CD8 T cell response following whole Plasmodium vaccination. Methods Mol Biol, 923, 493-504. PMID: 22990800.

Zander, R. A., Butler, N. S. (2013). Dysfunctional adaptive immunity during parasitic infections. Curr Immunol Rev, 9(3), 179-89. PMID: 24839433.

Butler, N. S. (2013). Vaccination Against Malaria Parasites: Paradigms, Perils and Progress. In M. Geist (Eds.) Molecular Vaccines-From Prophylaxis to Therapy. Vienna: Springer Press.

Illingworth, J., Butler, N. S., Roetynck, S., Mwacharo, J., Pierce, S. K., Bejon, P., Crompton, P. D., Marsh, K. & Ndungu, F. M. (2013). Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. The Journal of Immunology, 190(3), 1038-47. PMID: 23264654.

Butler, N. S., Harris, T. H. & Blader, I. J. (2013). Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?. Trends in Parasitology, 29(12), 593-602. PMID: 24184186.

Butler, N. S., Vaughan, A. M., Harty, J. T. & Kappe, S. H. (2012). Whole parasite vaccination approaches for prevention of malaria infection. Trends in Immunology, 33(5), 247-54. PMID: 22405559.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2011). Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. The Journal of Immunology, 186(10), 5873-84. PMID: 21460205.

Butler, N. S., Nolz, J. C. & Harty, J. T. (2011). Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol, 13(7), 925-33. PMID: 21501363.

Butler, N. S., Schmidt, N. W., Vaughan, A. M., Aly, A. S., Kappe, S. H. & Harty, J. T. (2011). Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host & Microbe, 9(6), 451-62. PMID: 21669394.

Butler, N. S., Moebius, J., Pewe, L. L., Traore, B., Doumbo, O. K., Tygrett, L. T., Waldschmidt, T. J., Crompton, P. D. & Harty, J. T. (2011). Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nature Immunology, 13(2), 188-95. PMID: 22157630.

Schmidt, N. W., Butler, N. S., Badovinac, V. P. & Harty, J. T. (2010). Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathogens, 6(7), e1000998. PMID: 20657824.

Butler, N. S., Schmidt, N. W. & Harty, J. T. (2010). Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. The Journal of Immunology, 184(5), 2528-38. PMID: 20097864.

Butler, N. S., Harty, J. T. (2010). The role of inflammation in the generation and maintenance of memory T cells. In  Adv Exp Med Biol. pp. 42-56.  PMID: 20795539.

Butler, N. S., Harty, J. T. (2009). A "memorable" NK cell discovery. (Vols. 19). (3), pp. 277-8. Cell ResearchPMID: 19252510.

Schmidt, N. W., Butler, N. S. & Harty, J. T. (2009). CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge. Vaccine, 27(44), 6103-6. PMID: 19712771.

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Structural and biological basis of CTL escape in coronavirus-infected mice. The Journal of Immunology, 180(6), 3926-37. PMID: 18322201.

Schmidt, N. W., Podyminogin, R. L., Butler, N. S., Badovinac, V. P., Tucker, B. J., Bahjat, K. S., Lauer, P., Reyes-Sandoval, A., Hutchings, C. L., Moore, A. C., Gilbert, S. C., Hill, A. V., Bartholomay, L. C. & Harty, J. T. (2008). Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A, 105(37), 14017-22. PMID: 18780790.

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S. (2008). Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. PLoS Pathogens, 4(10), e1000186. PMID: 18949029.

Butler, N. S., Dandekar, A. A. & Perlman, S. (2007). Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus. J Virol, 81(24), 13291-8. PMID: 17913802.

Perlman, S., Butler, N. (2006). Neurotropic coronavirus infections. In C. S. Reiss (Eds.) Neurotropic Viral Infections. New York: Cambridge University Press.

Yarovinsky, T. O., Butler, N. S., Monick, M. M. & Hunninghake, G. W. (2006). Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. The Journal of Immunology, 177(7), 4426-35. PMID: 16982877.

Butler, N., Pewe, L., Trandem, K. & Perlman, S. (2006). Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology, 347(2), 410-21. PMID: 16413043.

Ashare, A., Powers, L. S., Butler, N. S., Doerschug, K. C., Monick, M. M. & Hunninghake, G. W. (2005). Anti-inflammatory response is associated with mortality and severity of infection in sepsis. Am J Physiol Lung Cell Mol Physiol, 288(4), L633-40. PMID: 15579629.

Monick, M. M., Cameron, K., Powers, L. S., Butler, N. S., McCoy, D., Mallampalli, R. K. & Hunninghake, G. W. (2004). Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol, 30(6), 844-52. PMID: 14742298.

Chung, M. P., Monick, M. M., Hamzeh, N. Y., Butler, N. S., Powers, L. S. & Hunninghake, G. W. (2003). Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol, 29(3 Pt 1), 375-80. PMID: 12676806.

Monick, M. M., Powers, L. S., Butler, N. S. & Hunninghake, G. W. (2003). Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. The Journal of Immunology, 171(5), 2625-30. PMID: 12928415.

Monick, M. M., Samavati, L., Butler, N. S., Mohning, M., Powers, L. S., Yarovinski, T., Spitz, D. R. & Hunninghake, G. W. (2003). Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol, 171(10), 5107-15. PMID: 14607909.

Yarovinsky, T. O., Powers, L. S., Butler, N. S., Bradford, M. A., Monick, M. M. & Hunninghake, G. W. (2003). Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance. J Immunol, 171(5), 2453-60. PMID: 12928393.

Monick, M. M., Yarovinsky, T. O., Powers, L. S., Butler, N. S., Carter, A. B., Gudmundsson, G. & Hunninghake, G. W. (2003). Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem, 278(52), 53035-44. PMID: 14565959.

Nyunoya, T., Powers, L. S., Yarovinsky, T. O., Butler, N. S., Monick, M. M. & Hunninghake, G. W. (2003). Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein. J Biol Chem, 278(38), 36099-106. PMID: 12847100.

Monick, M. M., Powers, L., Butler, N., Yarovinsky, T. & Hunninghake, G. W. (2002). Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol, 283(2), L390-402. PMID: 12114201.

Monick, M. M., Robeff, P. K., Butler, N. S., Flaherty, D. M., Carter, A. B., Peterson, M. W. & Hunninghake, G. W. (2002). Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem, 277(36), 32992-3000. PMID: 12072439.

Butler, N. S., Monick, M. M., Yarovinsky, T. O., Powers, L. S. & Hunninghake, G. W. (2002). Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol, 169(7), 3700-9. PMID: 12244163.